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Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas

1 Oct 2011

Abstract excerpt

AIMS: To investigate whether Oct4, Sox2 and Nanog, three core regulatory factors maintaining pluripotency and self-renewal of embryonic stem cells (ESCs), are coexpressed in human gliomas, and whether their expression might be linked to carcinogenesis and the formation of cancer stem cells (CSCs). METHODS AND RESULTS: Forty cases of human glioma were examined. The expression of Oct4, Sox2 and Nanog was analysed...

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PMID: 22014056
DOI: 10.1111/j.1365-2559.2011.03993.x

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