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Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities

20 Oct 2011

Abstract excerpt

The ORF3b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) has a nuclear localization signal (NLS) at its C terminus and antagonizes interferon (IFN) function by modulating the activity of IFN regulatory factor 3 (IRF3). SARS-like coronaviruses (SL-CoVs) found in bats share an identical genome organization and high sequence identity for most of their gene products. In this study, ORF3b...

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PMID: 22012463
DOI: 10.1099/vir.0.033589-0

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