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Article

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.

The Journal of clinical investigation - 1 Jul 2011

Lehmann Brian D, Bauer Joshua A, Chen Xi, Sanders Melinda E, Chakravarthy A Bapsi, Shyr Yu, Pietenpol Jennifer A

Abstract excerpt

Triple-negative breast cancer (TNBC) is a highly diverse group of cancers, and subtyping is necessary to better identify molecular-based therapies. In this study, we analyzed gene expression (GE) profiles from 21 breast cancer data sets and identified 587 TNBC cases. Cluster analysis identified 6 TNBC subtypes displaying unique GE and ontologies, including 2 basal-like (BL1 and BL2), an immunomodulatory (IM), a...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21633166
DOI: 10.1172/JCI45014
PMCID: PMC3127435

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