Article

One-pot synthesis and biological evaluation of N-fused imidazoles as antibacterial agents and bacterial topoisomerase inhibitors

2025-03-13

Abstract excerpt

A series of N -fused imidazoles related to known inhibitors of human topoisomerase IIα were rapidly synthesized by a multicomponent GBB reaction under environmentally friendly conditions with microwave heating. Two of the compounds synthesized exhibited bacteriostatic activity against methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria, but none showed significant inhibition of bact...

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Literature Corpus work: 4e022b90-8624-50d0-9887-288216a6c5c0
DOI: 10.1016/j.rechem.2025.102191

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