Article
Insulin binding to brain capillaries is reduced in genetically obese, hyperinsulinemic Zucker rats.
Peptides - 1 Jan 2000
Schwartz M W, Figlewicz D F, Kahn S E, Baskin D G, Greenwood M R, Porte D
Abstract excerpt
In order to study the role of plasma insulin in regulating the binding of insulin to the endothelium of the blood-brain barrier (BBB), insulin binding to a purified preparation of brain capillaries was measured in both genetically obese Zucker rats and lean Zucker controls. We found a reduction of 65% in brain capillary insulin binding site number in the obese compared to lean rats with no change in receptor...
Topics
- Animals
- Binding, Competitive
- Blood Glucose
- Brain
- Capillaries
- Genotype
- Hyperinsulinism
- In Vitro Techniques
- Insulin
- Iodine Radioisotopes
- Liver
- Obesity