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Article

The effects of 17β-estradiol and a selective estrogen receptor modulator, bazedoxifene, on ovarian carcinogenesis.

Gynecologic oncology - 1 Jan 2012

Romero Iris L, Lee WooSeok, Mitra Anirban K, Gordon Ilyssa O, Zhao Yan, Leonhardt Payton, Penicka Carla V, Mui Keeley L, Krausz Thomas N, Greene Geoffrey L, Lengyel Ernst

Abstract excerpt

OBJECTIVE: To test if estrogen promotes carcinogenesis in vitro and in a genetic mouse model of ovarian cancer and whether its effects can be inhibited by a novel selective estrogen receptor modulator (SERM), bazedoxifene. METHODS: Bazedoxifene was synthesized and it was confirmed that the drug abrogated the uterine stimulatory effect of 17β-estradiol in mice. To determine if hormones alter tumorigenesis in vivo...

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Source

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Identifiers

PMID: 21996264
DOI: 10.1016/j.ygyno.2011.08.026
PMCID: PMC3249832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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