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Article

Evolution of diterpene metabolism: Sitka spruce CYP720B4 catalyzes multiple oxidations in resin acid biosynthesis of conifer defense against insects.

Plant physiology - 1 Dec 2011

Hamberger Björn, Ohnishi Toshiyuki, Hamberger Britta, Séguin Armand, Bohlmann Jörg

Abstract excerpt

Diterpene resin acids (DRAs) are specialized (secondary) metabolites of the oleoresin defense of conifers produced by diterpene synthases and cytochrome P450s of the CYP720B family. The evolution of DRA metabolism shares common origins with the biosynthesis of ent-kaurenoic acid, which is highly conserved in general (primary) metabolism of gibberellin biosynthesis. Transcriptome mining in species of spruce...

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PMID: 21994349
DOI: 10.1104/pp.111.185843
PMCID: PMC3327196

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