Article
Hereditary lysozyme amyloidosis -- phenotypic heterogeneity and the role of solid organ transplantation.
Journal of internal medicine - 1 Jul 2012
Sattianayagam P T, Gibbs S D J, Rowczenio D, Pinney J H, Wechalekar A D, Gilbertson J A, Hawkins P N, Lachmann H J, Gillmore J D
Abstract excerpt
OBJECTIVES: Lysozyme amyloidosis (ALys) is a form of hereditary systemic non-neuropathic amyloidosis, which is inherited in an autosomal dominant fashion. Lysozyme, which is the amyloidogenic precursor protein in ALys, is a ubiquitous bacteriolytic enzyme synthesized by hepatocytes, polymorphs and macrophages. The aim of this study is to describe the phenotype and outcome of patients with ALys including the role...
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