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Article

Genetic variation in CNTNAP2 alters brain function during linguistic processing in healthy individuals.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2011

Whalley Heather C, O'Connell Garret, Sussmann Jessika E, Peel Anna, Stanfield Andrew C, Hayiou-Thomas Marianna E, Johnstone Eve C, Lawrie Stephen M, McIntosh Andrew M, Hall Jeremy

Abstract excerpt

Language impairments are a characteristic feature of autism and related autism spectrum disorders (ASDs). Autism is also highly heritable and one of the most promising candidate genes implicated in its pathogenesis is contactin-associated protein-like 2 (CNTNAP2), a gene also associated with language impairment. In the current study we investigated the functional effects of variants of CNTNAP2 associated with...

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Source

Identifiers

PMID: 21987501
DOI: 10.1002/ajmg.b.31241

Genes

CNTNAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in CNTNAP2 alters brain function during linguistic processing in healthy individuals.PMID 21987501Read ↗

Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2.Semantic proximity Read ↗

Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene.Semantic proximity Read ↗

Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2.Semantic proximity Read ↗

Common variation in the autism risk gene CNTNAP2, brain structural connectivity and multisensory speech integration.Semantic proximity Read ↗

A common genetic variant in the Neurexin family member CNTNAP2 is related to language but not communication skills in youth with Autism Spectrum Disorder.Semantic proximity Read ↗

A common variant of the CNTNAP2 gene is associated with structural variation in the left superior occipital gyrus.Semantic proximity Read ↗

A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism.Semantic proximity Read ↗

Variants of the CNTNAP2 5' promoter as risk factors for autism spectrum disorders: a genetic and functional approach.Semantic proximity Read ↗

A common variant of CNTNAP2 is associated with sub-threshold autistic traits and intellectual disability.Semantic proximity Read ↗

Associations between the CNTNAP2 gene, dorsolateral prefrontal cortex, and cognitive performance on the Stroop task.Semantic proximity Read ↗

Shining a light on CNTNAP2: complex functions to complex disorders.Semantic proximity Read ↗

CNTNAP2 variants affect early language development in the general population.Semantic proximity Read ↗

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