Article
Immunogenicity of meningococcus C vaccination in a patient with atypical hemolytic uremic syndrome (aHUS) on eculizumab therapy.
Pediatric transplantation - 1 Sept 2012
Zlamy Manuela, Hofer Johannes, Elias Johannes, Vogel Ulrich, Frosch Matthias, Jungraithmayr Therese, Zimmerhackl Lothar Bernd, Prelog Martina
Abstract excerpt
We report successful kidney transplantation in a 10-yr-old boy with aHUS and heterozygous factor H mutation using the terminal complement inhibitor eculizumab to avoid recurrence of aHUS in the renal graft. Vaccination against meningococcus C (Men C) is essential in patients with dysfunction of the complement system, as induced by eculizumab. In our patient, we report waning SBA titers but maintenance of...
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