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Article

Major histocompatibility complex and strong human leukocyte antigen-DRB1 and gender association with Vogt-Koyanagi-Harada syndrome in Mexican Mestizos.

Human immunology - 1 Dec 2011

Aláez Carmen, Flores-A Hilario, Concha del Río Luz Elena, Munguía Andrea, Rodríguez Araceli, García David, Arellanes Lourdes, Gorodezky Clara

Abstract excerpt

Vogt-Koyanagi-Harada syndrome (VKH) is a multisystem autoimmune disorder mediated by cytotoxic T cells targeting melanocytes antigen(s). A strong major histocompatibility complex (MHC) association with HLA-DRB1*04:05 has been demonstrated in different populations. We investigated the contribution of HLA-A*, -B*, -C*, -DRB1*, and -DQB1* genes, belonging to the human leukocyte antigen (HLA), to the expression of...

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PMID: 21964432
DOI: 10.1016/j.humimm.2011.09.002

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