Article
Genome-wide association study identifies HMGN3 locus for spine bone size variation in Chinese.
Human genetics - 1 Mar 2012
Lei Shu-Feng, Shen Hui, Yang Tie-Lin, Guo Yan, Dong Shan-Shan, Xu Xiang-Hong, Deng Fei-Yan, Tian Qing, Liu Yong-Jun, Liu Yao-Zhong, Li Jian, Deng Hong-Wen
Abstract excerpt
Bone size (BS) is one of the major risk factors for osteoporotic fractures. BS variation is genetically determined to a substantial degree with heritability over 50%, but specific genes underlying variation of BS are still largely unknown. To identify specific genes for BS in Chinese, initial genome-wide association scan (GWAS) study and follow-up replication study were performed. In initial GWAS study, a group...
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