Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemokine receptor 5 knockout strategies

2 Nov 2010

Abstract excerpt

PURPOSE OF REVIEW: Individuals homozygous for a deletion in the chemokine receptor 5 (CCR5) gene (CCR5Δ32) are almost completely resistant to HIV-1 infection. A recent report that transplantation of hematopoietic stem or progenitor cells (HSCs) from a CCR5Δ32 homozygous donor effectively cured an HIV patient has increased interest in the development of strategies that could be used to recreate this phenotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine receptors and signaling
Share to HIV Research and Treatment
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21242897
DOI: 10.1097/coh.0b013e32834122d7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemokine receptor 5 knockout strategiesPMID 21242897Read ↗

Gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induces resistance to CCR5-using HIV-1Semantic proximity Read ↗

Genomic Editing of the HIV-1 Coreceptor CCR5 in Adult Hematopoietic Stem and Progenitor Cells Using Zinc Finger NucleasesSemantic proximity Read ↗

CCR5-edited gene therapies for HIV cure: Closing the door to viral entry.Semantic proximity Read ↗

The clinical applications of genome editing in HIVSemantic proximity Read ↗

Preclinical Evaluation of a Novel TALEN Targeting CCR5 Confirms Efficacy and Safety in Conferring Resistance to HIV‐1 InfectionSemantic proximity Read ↗

Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids.Semantic proximity Read ↗

mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5.Semantic proximity Read ↗

CRISPR/Cas9-Mediated CCR5 Ablation in Human Hematopoietic Stem/Progenitor Cells Confers HIV-1 Resistance In Vivo.Semantic proximity Read ↗

Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cellsSemantic proximity Read ↗

Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5.Semantic proximity Read ↗

Generation of an HIV Resistant T-cell Line by Targeted “Stacking” of Restriction FactorsSemantic proximity Read ↗

Biallelic, Selectable, Knock-in Targeting of CCR5 via CRISPR-Cas9 Mediated Homology Directed Repair Inhibits HIV-1 Replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.