Article
Maternal inheritance of familial hypercholesterolemia caused by the V408M low-density lipoprotein receptor mutation increases mortality.
Atherosclerosis - 1 Dec 2011
Versmissen Jorie, Botden Ilse P G, Huijgen Roeland, Oosterveer Daniëlla M, Defesche Joep C, Heil Thea C, Muntz Anouk, Langendonk Janneke G, Schinkel Arend F L, Kastelein John J P, Sijbrands Eric J G
Abstract excerpt
OBJECTIVE: Fetal exposure to maternal hypercholesterolemia increases the extent of fatty-streak formation in fetal aortas as well as the rate of progression, and may therefore increase coronary heart disease (CHD) risk later in life. We hypothesized that the risk of CHD in untreated individuals with familial hypercholesterolemia (FH) is more extreme when the disease is transmitted maternally. METHODS: In a large...
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