Article
Dyslipidemia of mothers with familial hypercholesterolemia deteriorates lipids in adult offspring.
Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2010
van der Graaf Anouk, Vissers Maud N, Gaudet Daniel, Brisson Diane, Sivapalaratnam Suthesh, Roseboom Tessa J, Jansen Angelique C M, Kastelein John J P, Hutten Barbara A
Abstract excerpt
OBJECTIVE: It is unknown whether elevated maternal low-density lipoprotein cholesterol (LDL-C) levels lead to dyslipidemia in the offspring. Because this could have important consequences for cardiovascular prevention in mother and child, we explored the relationship between maternal familial hypercholesterolemia (FH) and lipids in adult offspring. METHODS AND RESULTS: In a large cohort of both Dutch and Canadian...
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