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Article

The phospho-landscape of the survival of motoneuron protein (SMN) protein: relevance for spinal muscular atrophy (SMA).

Cellular and molecular life sciences : CMLS - 25 Aug 2022

Detering Nora Tula, Schüning Tobias, Hensel Niko, Claus Peter

Abstract excerpt

Spinal muscular atrophy (SMA) is caused by low levels of the survival of motoneuron (SMN) Protein leading to preferential degeneration of lower motoneurons in the ventral horn of the spinal cord and brain stem. However, the SMN protein is ubiquitously expressed and there is growing evidence of a multisystem phenotype in SMA. Since a loss of SMN function is critical, it is important to decipher the regulatory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36006469
DOI: 10.1007/s00018-022-04522-9
PMCID: PMC11071818

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