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Article

Adaptive evolution of Staphylococcus aureus during chronic endobronchial infection of a cystic fibrosis patient.

PloS one - 1 Jan 2011

McAdam Paul R, Holmes Anne, Templeton Kate E, Fitzgerald J Ross

Abstract excerpt

The molecular adaptation of Staphylococcus aureus to its host during chronic infection is not well understood. Comparative genome sequencing of 3 S. aureus isolates obtained sequentially over 26 months from the airways of a cystic fibrosis patient, revealed variation in phage content, and genetic polymorphisms in genes which influence antibiotic resistance, and global regulation of virulence. The majority of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21912685
DOI: 10.1371/journal.pone.0024301
PMCID: PMC3166311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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