Neutrophil Extracellular Trap (NET)-Mediated Killing of Pseudomonas aeruginosa: Evidence of Acquired Resistance within the CF Airway, Independent of CFTR

Abstract excerpt

The inability of neutrophils to eradicate Pseudomonas aeruginosa within the cystic fibrosis (CF) airway eventually results in chronic infection by the bacteria in nearly 80 percent of patients. Phagocytic killing of P. aeruginosa by CF neutrophils is impaired due to decreased cystic fibrosis transmembrane conductance regulator (CFTR) function and virulence factors acquired by the bacteria. Recently, neutrophil...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bacterial biofilms and quorum sensing
• Share to Cystic Fibrosis Research Advances
• Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms