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Article

Assessment of tyrosinase variants and skin cancer risk in a large cohort of French subjects.

Journal of dermatological science - 1 Nov 2011

Hu Hui-Han, Guedj Mickael, Descamps Vincent, Jouary Thomas, Bourillon Agnes, Ezzedine Khaled, Taieb Alain, Bagot Martine, Bensussan Armand, Saiag Philippe, Grandchamp Bernard, Basset-Seguin Nicole, Soufir Nadem

Abstract excerpt

BACKGROUND: Tyrosinase (TYR) is a key pigmentation gene that is highly polymorphic and responsible for the most common form of autosomal recessive albinism, OCA1. OBJECTIVE: To assess the role of frequent and rare TYR variants in predisposition to skin cancer (SK) in the French population. METHODS: We genotyped a frequent TYR variant (p.R402Q) in 1273 patients {1047 cutaneous melanoma (CM) and 226 basal cell...

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Identifiers

PMID: 21906913
DOI: 10.1016/j.jdermsci.2011.07.003

Genes

TYR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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