Article
Mechanisms of vanadate-induced cellular toxicity: role of cellular glutathione and NADPH.
Archives of biochemistry and biophysics - 1 Oct 2002
Capella Luiz S, Gefé Maria R, Silva Edson F, Affonso-Mitidieri Ottilia, Lopes Anibal G, Rumjanek Vivian M, Capella Márcia A M
Abstract excerpt
Besides its insulin-mimetic effects, vanadate is also known to have a variety of physiological and pharmacological properties, varying from induction of cell growth to cell death and is also a modulator of the multidrug resistance phenotype. However, the mechanisms underlying these effects are still not understood. The present report analyzes the mechanisms of vanadate toxicity in two cell lines previously found...
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