Transdifferentiation from cornea to lens in Xenopus laevis depends on BMP signalling and involves upregulation of Wnt signalling

Abstract excerpt

BACKGROUND: Surgical removal of the lens from larval Xenopus laevis results in a rapid transdifferention of central corneal cells to form a new lens. The trigger for this process is understood to be an induction event arising from the unprecedented exposure of the cornea to the vitreous humour that occurs following lens removal. The molecular identity of this trigger is unknown. RESULTS: Here, we have used a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Connexins and lens biology
• Share to Developmental Biology and Gene Regulation
• Share to Intraocular Surgery and Lenses