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Article

Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer.

Journal of translational medicine - 5 Sept 2011

Scholten Kirsten B J, Turksma Annelies W, Ruizendaal Janneke J, van den Hende Muriel, van der Burg Sjoerd H, Heemskerk Mirjam H M, Meijer Chris J L M, Hooijberg Erik

Abstract excerpt

BACKGROUND: Infection with high risk Human Papilloma Virus (HPV) is associated with cancer of the cervix, vagina, penis, vulva, anus and some cases of head and neck carcinomas. The HPV derived oncoproteins E6 and E7 are constitutively expressed in tumor cells and therefore potential targets for T cell mediated adoptive immunotherapy. Effective immunotherapy is dependent on the presence of both CD4+ and CD8+ T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Histocompatibility Antigens Class II

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Share to Oncogene Proteins, Viral

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocytes, Helper-Inducer

Source

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Identifiers

PMID: 21892941
DOI: 10.1186/1479-5876-9-147
PMCID: PMC3176193

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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