Article
A modified FCCS procedure applied to Ly49A-MHC class I cis-interaction studies in cell membranes.
Biophysical journal - 7 Sept 2011
Strömqvist Johan, Johansson Sofia, Xu Lei, Ohsugi Yu, Andersson Katja, Muto Hideki, Kinjo Masataka, Höglund Petter, Widengren Jerker
Abstract excerpt
The activity of natural killer (NK) cells is regulated by a fine-tuned balance between activating and inhibitory receptors. Dual-color fluorescence cross-correlation spectroscopy (FCCS) was used to directly demonstrate a so-called cis-interaction between a member of the inhibitory NK cell receptor family Ly49 (Ly49A), and its ligand, the major histocompatibility complex (MHC) class I, within the plasma membrane...
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