Article
Ultrasound and microbubble-assisted gene delivery in Achilles tendons: long lasting gene expression and restoration of fibromodulin KO phenotype.
Journal of controlled release : official journal of the Controlled Release Society - 10 Dec 2011
Delalande Anthony, Bouakaz Ayache, Renault Gilles, Tabareau Flore, Kotopoulis Spiros, Midoux Patrick, Arbeille Brigitte, Uzbekov Rustem, Chakravarti Shukti, Postema Michiel, Pichon Chantal
Abstract excerpt
The aim of this study is to deliver genes in Achilles tendons using ultrasound and microbubbles. The rationale is to combine ultrasound-assisted delivery and the stimulation of protein expression induced by US. We found that mice tendons injected with 10 μg of plasmid encoding luciferase gene in the presence of 5×10⁵ BR14 microbubbles, exposed to US at 1 MHz, 200 kPa, 40% duty cycle for 10 min were efficiently...
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