Article
Lack of association between chemokine receptor 5 (CCR5) δ32 mutation and pathogenesis of asthma in Iranian patients.
Southern medical journal - 1 Jun 2011
Abousaidi Hamid, Vazirinejad Reza, Arababadi Mohammad Kazemi, Rafatpanah Houshang, Pourfathollah Ali Akbar, Derakhshan Reza, Daneshmandi Saeed, Hassanshahi Gholamhossein
Abstract excerpt
BACKGROUND: Chemokines and their receptors are clinically important mediators, as the chemokine receptors are expressed on almost all immune cells. They play pivotal roles in pathogenesis of almost all clinical situations including asthma. Correspondingly, MIP-1α (CCL3), MIP-1β (CCL4), and RANTES (CCL5) are among the important chemokines involved in the pathogenesis of asthma. These chemokines bind to the CCR5...
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