A functional variant in the thrombospondin-1 gene and the risk of small for gestational age infants.

doi:10.1111/j.1538-7836.2011.04494.x

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Article

A functional variant in the thrombospondin-1 gene and the risk of small for gestational age infants.

Journal of thrombosis and haemostasis : JTH - 1 Nov 2011

Andraweera P H, Dekker G A, Thompson S D, North R A, McCowan L M E, Roberts C T

Abstract excerpt

INTRODUCTION: Thrombospondin-1 (TSP-1) is a prothrombotic and anti-angiogenic glycoprotein expressed in the placenta. A functional single nucleotide polymorphism in the TSP-1 gene (TSP-1 A2210G) is a risk factor for familial premature myocardial infarction. Small for gestational age (SGA) infants are at increased risk of coronary artery disease in adult life and common genetic factors may underlie both...

Topics

Adult
Coronary Artery Disease
Female
Genetic Predisposition to Disease
Humans
Infant, Newborn
Infant, Small for Gestational Age
Myocardial Infarction
Polymorphism, Single Nucleotide
Pregnancy
Risk
Thrombospondin 1
Young Adult

Source

Open in PubMed

Identifiers

PMID: 21883885
DOI: 10.1111/j.1538-7836.2011.04494.x

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