Article
Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesis.
Lipids - 1 Jan 2012
Shackleton Cedric H L
Abstract excerpt
In 1937 Butler and Marrian found large amounts of the steroid pregnanetriol in urine from a patient with the adrenogenital syndrome, a virilizing condition known to be caused by compromised adrenal secretion even in this pre-cortisol era. This introduced the concept of the study of altered excretion of metabolites as an in vivo tool for understanding sterol and steroid biosynthesis. This approach is still viable...
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