Article
Alteration of marrow cell gene expression, protein production, and engraftment into lung by lung-derived microvesicles: a novel mechanism for phenotype modulation.
Stem cells (Dayton, Ohio) - 1 Sept 2007
Aliotta Jason M, Sanchez-Guijo Fermin M, Dooner Gerri J, Johnson Kevin W, Dooner Mark S, Greer Kenneth A, Greer Deborah, Pimentel Jeffrey, Kolankiewicz Luiz M, Puente Napoleon, Faradyan Sam, Ferland Paulette, Bearer Elaine L, Passero Michael A, Adedi Mehrdad, Colvin Gerald A, Quesenberry Peter J
Abstract excerpt
Numerous animal studies have demonstrated that adult marrow-derived cells can contribute to the cellular component of the lung. Lung injury is a major variable in this process; however, the mechanism remains unknown. We hypothesize that injured lung is capable of inducing epigenetic modifications of marrow cells, influencing them to assume phenotypic characteristics of lung cells. We report that under certain...
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