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Adaptive variation in butyrylcholinesterase-influenced lipid metabolism during horse domestication

20 Aug 2026

Abstract excerpt

Lipid metabolism influences horse athletic performance, yet its genetic basis remains unclear. Here, we investigate the genetic basis of lipid metabolic traits by quantifying key metabolic parameters and sequencing the genomes of 298 horses. We identify a missense mutation (ECA19:9,198,989, G>C) in the BCHE gene that is strongly associated with lipid metabolism, especially butyrylcholinesterase (BChE) activity....

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Share to Cholinesterase and Neurodegenerative Diseases
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PMID: 42623242
DOI: 10.1016/j.celrep.2026.117879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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