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Article

FAN1 variants identified in multiple-case early-onset breast cancer families via exome sequencing: no evidence for association with risk for breast cancer.

Breast cancer research and treatment - 1 Dec 2011

Park Daniel J, Odefrey Fabrice A, Hammet Fleur, Giles Graham G, Baglietto Laura, ABCFS, MCCS, Hopper John L, Schmidt Daniel F, Makalic Enes, Sinilnikova Olga M, Goldgar David E, Southey Melissa C

Abstract excerpt

We are interested in the characterisation of previously undescribed contributions to the heritable component of human cancers. To this end, we applied whole-exome capture, followed by massively parallel sequence analysis to the germline DNA of two greater than third-degree affected relatives from four multiple-case, early-onset breast cancer families. Prior testing for variants in known breast cancer...

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PMID: 21858661
DOI: 10.1007/s10549-011-1704-y

Genes

FAN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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