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Article

Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase.

PloS one - 1 Jan 2011

Haagsma Anna C, Podasca Ioana, Koul Anil, Andries Koen, Guillemont Jerome, Lill Holger, Bald Dirk

Abstract excerpt

Infections with Mycobacterium tuberculosis are substantially increasing on a worldwide scale and new antibiotics are urgently needed to combat concomitantly emerging drug-resistant mycobacterial strains. The diarylquinoline TMC207 is a highly promising drug candidate for treatment of tuberculosis. This compound kills M. tuberculosis by binding to a new target, mycobacterial ATP synthase. In this study we used...

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Identifiers

PMID: 21858172
DOI: 10.1371/journal.pone.0023575
PMCID: PMC3157398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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