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Article

Kbus/Idr, a mutant mouse strain with skeletal abnormalities and hypophosphatemia: identification as an allele of 'Hyp'.

Journal of biomedical science - 20 Aug 2011

Moriyama Kenji, Hanai Atsuko, Mekada Kazuyuki, Yoshiki Atsushi, Ogiwara Katsueki, Kimura Atsushi, Takahashi Takayuki

Abstract excerpt

BACKGROUND: The endopeptidase encoded by Phex (phosphate-regulating gene with homologies to endopeptidases linked to the X chromosome) is critical for regulation of bone matrix mineralization and phosphate homeostasis. PHEX has been identified from analyses of human X-linked hypophosphatemic rickets and Hyp mutant mouse models. We here demonstrated a newly established dwarfism-like Kbus/Idr mouse line to be a...

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Source

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Identifiers

PMID: 21854633
DOI: 10.1186/1423-0127-18-60
PMCID: PMC3175157

Genes

PHEX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kbus/Idr, a mutant mouse strain with skeletal abnormalities and hypophosphatemia: identification as an allele of 'Hyp'.PMID 21854633Read ↗

New intragenic deletions in the Phex gene clarify X-linked hypophosphatemia-related abnormalities in mice.Semantic proximity Read ↗

Evidence for Phex haploinsufficiency in murine X-linked hypophosphatemia.Semantic proximity Read ↗

Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype.Semantic proximity Read ↗

Developmental Expression and Tissue Distribution of Phex Protein: Effect of the <i>Hyp</i> Mutation and Relationship to Bone MarkersSemantic proximity Read ↗

Characterization of Novel PHEX Variants in X-linked Hypophosphatemic Rickets and Genotype-PHEX Activity Correlation.Semantic proximity Read ↗

Genetic screening for X-linked hypophosphatemic mice and ontogenic characterization of the defect in the renal sodium-phosphate transporter.Semantic proximity Read ↗

Pex Gene Deletions in Gy and Hyp Mice Provide Mouse Models for X-Linked HypophosphatemiaSemantic proximity Read ↗

New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis.Semantic proximity Read ↗

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression.Semantic proximity Read ↗

Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.Semantic proximity Read ↗

Hexa-D-arginine treatment increases 7B2•PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype.Semantic proximity Read ↗

Increased bone volume and correction of HYP mouse hypophosphatemia in the Klotho/HYP mouse.Semantic proximity Read ↗

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