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Article

Frequent Alteration of MLL3 Frameshift Mutations in Microsatellite Deficient Colorectal Cancer

11 Aug 2011

Abstract excerpt

BACKGROUND: MLL3 is a histone 3-lysine 4 methyltransferase with tumor-suppressor properties that belongs to a family of chromatin regulator genes potentially altered in neoplasia. Mutations in MLL3 were found in a whole genome analysis of colorectal cancer but have not been confirmed by a separate study. METHODS AND RESULTS: We analyzed mutations of coding region and promoter methylation in MLL3 using 126 cases...

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PMID: 21853109
DOI: 10.1371/journal.pone.0023320

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