Article
Searching for surrogates for IGHV mutations in chronic lymphocytic leukemia.
Leukemia research - 1 Nov 2011
Hamblin Terry J
Abstract excerpt
Despite a startling separation of chronic lymphocytic leukemia (CLL) into two clinically different diseases with average survivals of 8 years and 25 years, the mutational status of immunoglobulin variable region (IGHV) genes has not entered routine clinical practice to assess prognosis, although its assessment is regarded as an essential for clinical trials. Instead, surrogates that may be measured by flow...
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