Article
Attenuation of virulence in an apicomplexan hemoparasite results in reduced genome diversity at the population level.
BMC genomics - 12 Aug 2011
Lau Audrey Ot, Kalyanaraman Ananth, Echaide Ignacio, Palmer Guy H, Bock Russell, Pedroni Monica J, Rameshkumar Meenakshi, Ferreira Mariano B, Fletcher Taryn I, McElwain Terry F
Abstract excerpt
BACKGROUND: Virulence acquisition and loss is a dynamic adaptation of pathogens to thrive in changing milieus. We investigated the mechanisms of virulence loss at the whole genome level using Babesia bovis as a model apicomplexan in which genetically related attenuated parasites can be reliably derived from virulent parental strains in the natural host. We expected virulence loss to be accompanied by consistent...
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