Article
The risk of breast cancer in women with a BRCA1 mutation from North America and Poland.
International journal of cancer - 1 Jul 2012
Lubinski Jan, Huzarski Tomasz, Byrski Tomasz, Lynch Henry T, Cybulski Cezary, Ghadirian Parviz, Stawicka Malgorzata, Foulkes William D, Kilar Ewa, Kim-Sing Charmaine, Neuhausen Susan L, Armel Susan, Gilchrist Dawna, Sweet Kevin, Gronwald Jacek, Eisen Andrea, Gorski Bohdan, Sun Ping, Narod Steven A
Abstract excerpt
Women with a BRCA1 mutation face a high lifetime risk of breast cancer. It is unknown to what extent environmental factors modify the inherent genetic risk. If women from different countries, but with similar mutations, experience different levels of cancer risk, nongenetic risk modifiers are likely to be present. Study subjects were a cohort of 1477 women with a BRCA1 mutation, from Canada (n = 358), the United...
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