Article
Elevated FMR1 mRNA in premutation carriers is due to increased transcription.
RNA (New York, N.Y.) - 1 Apr 2007
Tassone Flora, Beilina Alexandra, Carosi Chiara, Albertosi Serena, Bagni Claudia, Li Lexin, Glover Kira, Bentley David, Hagerman Paul J
Abstract excerpt
Carriers of premutation alleles (55-200 CGG repeats) of the fragile X mental retardation 1 (FMR1) gene have levels of FMR1 mRNA that are elevated by as much as 10-fold in peripheral blood leukocytes and CNS tissue. The excess expanded-repeat mRNA, per se, is now believed to result in forms of clinical involvement that are largely restricted to premutation carriers, including the neurodegenerative disorder,...
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