Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations.

doi:10.1371/journal.pgen.1002170

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Article

Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations.

PLoS genetics - 1 Jul 2011

Noguchi Emiko, Sakamoto Hiromi, Hirota Tomomitsu, Ochiai Kaori, Imoto Yoshimasa, Sakashita Masafumi, Kurosaka Fumitake, Akasawa Akira, Yoshihara Shigemi, Kanno Noriko, Yamada Yumi, Shimojo Naoki, Kohno Yoichi, Suzuki Yoichi, Kang Mi-Jin, Kwon Ji-Won, Hong Soo-Jong, Inoue Ken, Goto Yu-Ichi, Yamashita Fumio, Asada Takashi, Hirose Hiroshi, Saito Ikuo, Fujieda Shigeharu, Hizawa Nobuyuki, Sakamoto Toru, Masuko Hironori, Nakamura Yusuke, Nomura Ichiro, Tamari Mayumi, Arinami Tadao, Yoshida Teruhiko, Saito Hirohisa, Matsumoto Kenji

Abstract excerpt

Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(-8)) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421...

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Identifiers

PMID: 21814517
DOI: 10.1371/journal.pgen.1002170
PMCID: PMC3140987

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