Article
Allorecognition in the Tasmanian devil (Sarcophilus harrisii), an endangered marsupial species with limited genetic diversity.
PloS one - 1 Jan 2011
Kreiss Alexandre, Cheng Yuanyuan, Kimble Frank, Wells Barrie, Donovan Shaun, Belov Katherine, Woods Gregory M
Abstract excerpt
Tasmanian devils (Sarcophilus harrisii) are on the verge of extinction due to a transmissible cancer, devil facial tumour disease (DFTD). This tumour is an allograft that is transmitted between individuals without immune recognition of the tumour cells. The mechanism to explain this lack of immune recognition and acceptance is not well understood. It has been hypothesized that lack of genetic diversity at the...
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