Article
A phenotypic screen to identify hypertrophy-modulating microRNAs in primary cardiomyocytes.
Journal of molecular and cellular cardiology - 1 Jan 2012
Jentzsch Claudia, Leierseder Simon, Loyer Xavier, Flohrschütz Isabell, Sassi Yassine, Hartmann Dorothee, Thum Thomas, Laggerbauer Bernhard, Engelhardt Stefan
Abstract excerpt
MicroRNAs (miRNAs) are small non-coding RNAs that control expression of complementary target mRNAs. A growing number of miRNAs has been implicated in the pathogenesis of cardiac diseases, mostly based not on functional data, but on the observation that they are dysregulated in diseased myocardium. Consequently, our knowledge regarding a potential cardiac role of the majority of miRNAs is limited. Here, we report...
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