Article
Modulating distal cavities in the α and β subunits of human HbA reveals the primary ligand migration pathway.
Biochemistry - 30 Aug 2011
Birukou Ivan, Maillett David H, Birukova Anastasiya, Olson John S
Abstract excerpt
The free volume in the active site of human HbA plays a crucial role in governing the bimolecular rates of O(2), CO, and NO binding, the fraction of geminate ligand recombination, and the rate of NO dioxygenation by the oxygenated complex. We have decreased the size of the distal pocket by mutating Leu(B10), Val(E11), and Leu(G8) to Phe and Trp and that of other more internal cavities by filling them with Xe at...
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