Article
Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome.
Blood - 29 Sept 2011
McGowan Kelly A, Pang Wendy W, Bhardwaj Rashmi, Perez Marcelina G, Pluvinage John V, Glader Bertil E, Malek Reem, Mendrysa Susan M, Weissman Irving L, Park Christopher Y, Barsh Gregory S
Abstract excerpt
Reduced gene dosage of ribosomal protein subunits has been implicated in 5q- myelodysplastic syndrome and Diamond Blackfan anemia, but the cellular and pathophysiologic defects associated with these conditions are enigmatic. Using conditional inactivation of the ribosomal protein S6 gene in laboratory mice, we found that reduced ribosomal protein gene dosage recapitulates cardinal features of the 5q- syndrome,...
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