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Article

Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis.

Experimental hematology - 1 Apr 2012

Keel Siobán B, Phelps Susan, Sabo Kathleen M, O'Leary Monique N, Kirn-Safran Catherine B, Abkowitz Janis L

Abstract excerpt

Diamond-Blackfan anemia is a congenital hypoproliferative macrocytic anemia and 5q- syndrome myelodysplastic syndrome is an acquired hypoproliferative macrocytic anemia. Their common erythroid phenotype reflects a shared pathophysiology-haploinsufficiency of one of many ribosomal proteins and somatic deletion of one allele of the ribosomal protein S14 gene, respectively. Although these abnormalities lead to...

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Identifiers

PMID: 22198155
DOI: 10.1016/j.exphem.2011.12.003
PMCID: PMC3319152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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