Article
Tonsillar TLR9 expression and efficacy of tonsillectomy with steroid pulse therapy in IgA nephropathy patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Mar 2012
Sato Daisuke, Suzuki Yusuke, Kano Tatsuya, Suzuki Hitoshi, Matsuoka Joe, Yokoi Hidenori, Horikoshi Satoshi, Ikeda Katsuhisa, Tomino Yasuhiko
Abstract excerpt
BACKGROUND: Patients with IgA nephropathy (IgAN) often show aggravation of renal injury with macroscopic hematuria after mucosal infections, especially tonsillitis. We previously demonstrated the important role of mucosal Toll-like receptor 9 (TLR9) activation in the pathogenesis of murine IgAN. Moreover, a single nucleotide polymorphism (SNP) in TLR9 was significantly associated with pathological severity in...
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