Article
Prion induction by the short-lived, stress-induced protein Lsb2 is regulated by ubiquitination and association with the actin cytoskeleton.
Molecular cell - 22 Jul 2011
Chernova Tatiana A, Romanyuk Andrey V, Karpova Tatiana S, Shanks John R, Ali Moiez, Moffatt Nela, Howie Rebecca L, O'Dell Andrew, McNally James G, Liebman Susan W, Chernoff Yury O, Wilkinson Keith D
Abstract excerpt
Yeast prions are self-perpetuating, QN-rich amyloids that control heritable traits and serve as a model for mammalian amyloidoses. De novo prion formation by overproduced prion protein is facilitated by other aggregated QN-rich protein(s) and is influenced by alterations of protein homeostasis. Here we explore the mechanism by which the Las17-binding protein Lsb2 (Pin3) promotes conversion of the translation...
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