Article
Protective effect of recombinant human erythropoietin in type II Gaucher disease patient cells by scavenging endoplasmic reticulum stress.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Aug 2011
Cha Jeong-Rim, Kim Sung-Jo, Heo Tae-Hwe
Abstract excerpt
Gaucher disease (GD) is an inherited disorder characterized by excessive accumulation of glucocerebroside in cells due to a non-functional glucocerebrosidase that is linked to programmed cell death pathways. Although clinical manifestations vary, type II GD is the most severe phenotype characterized by endoplasmic reticulum (ER) stress, neurological dysfunction, and anemia. Recombinant human erythropoietin (EPO)...
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