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Article

MicroRNA-21 regulates the self-renewal of mouse spermatogonial stem cells

18 Jul 2011

Abstract excerpt

MicroRNAs (miRs) play a key role in the control of gene expression in a wide array of tissue systems, where their functions include the regulation of self-renewal, cellular differentiation, proliferation, and apoptosis. However, the functional importance of individual miRs in controlling spermatogonial stem cell (SSC) homeostasis has not been investigated. Using high-throughput sequencing, we profiled the...

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PMID: 21768389
DOI: 10.1073/pnas.1109987108

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