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Article

Mesenchymal stem cells show radioresistance <i>in vivo</i>

18 Jul 2011

Abstract excerpt

Irradiation impacts on the viability and differentiation capacity of tissue-borne mesenchymal stem cells (MSC), which play a pivotal role in bone regeneration. As a consequence of radiotherapy, bones may develop osteoradionecrosis. When irradiating human bone-derived MSC in vitro with increasing doses, the cells' self-renewal capabilities were greatly reduced. Mitotically stalled cells were still capable of...

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PMID: 21762375
DOI: 10.1111/j.1582-4934.2011.01383.x

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