Effects of irradiation on growth and differentiation-related gene expression in osteoblasts.

doi:10.1097/SCS.0b013e31822e5f66

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Article

Effects of irradiation on growth and differentiation-related gene expression in osteoblasts.

The Journal of craniofacial surgery - 1 Sept 2011

He Jie, Qiu Weiliu, Zhang Zhiyuan, Wang Zhonghe, Zhang Xiuli, He Yue

Abstract excerpt

Osteoblasts are bone-forming cells that are responsible for the production of bone extracellular matrix. Osteoradionecrosis is a complication of radiation therapy for carcinoma of the head and neck that occurs in 3% to 8.2% of irradiated patients. The irradiation effect on osteoblast differentiation has not been fully elucidated. The objective of our research was to elucidate the effects of radiation on the...

Topics

Alkaline Phosphatase
Analysis of Variance
Animals
Cell Cycle
Cell Differentiation
Cell Proliferation
Collagen
Dose-Response Relationship, Radiation
Gene Expression Regulation
Mice
Osteoblasts
Osteocalcin
Phenotype
X-Rays

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Open in PubMed

Identifiers

PMID: 21959403
DOI: 10.1097/SCS.0b013e31822e5f66

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