Article
Oestrogen receptor polymorphisms in female patients with rheumatoid arthritis.
Scandinavian journal of rheumatology - 1 Jan 2011
Dziedziejko V, Kurzawski M, Safranow K, Drozdzik M, Chlubek D, Pawlik A
Abstract excerpt
OBJECTIVES: Rheumatoid arthritis (RA) is a complex autoimmune disease with a strong genetic contribution in its pathogenesis. There is compelling evidence that autoimmunity is under genetic control and that oestrogens and their receptors (ESRs) can play a role in the high prevalence of RA in females. METHODS: A total of 318 female patients with RA and 250 controls were examined. Common single nucleotide...
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